Why You’ll Love this Homemade Italian Meatball Sub
When you’re craving comfort food that truly satisfies, this homemade Italian meatball sub delivers on every level.
Tender, juicy meatballs nestled in a warm, garlicky hoagie roll, smothered with rich tomato sauce and melty provolone cheese? Food heaven.
I love how these subs combine simple ingredients into something extraordinary.
The extra lean beef keeps things lighter, while the Italian seasonings infuse every bite with flavor.
And that moment when the cheese melts perfectly over everything? Pure magic.
Best part? You control the ingredients.
No mystery additives, just real food made with love.
What Ingredients are in Homemade Italian Meatball Sub?
Creating a mouthwatering meatball sub at home requires surprisingly simple ingredients that combine to make something truly spectacular. The heart of this recipe lies in perfectly seasoned meatballs, nestled in toasted garlic bread and blanketed with melty cheese. Most of these ingredients are pantry staples you probably already have on hand, making this an accessible comfort food for even novice cooks.
- 1 pound extra lean ground beef
- 3/4 cup Italian seasoned breadcrumbs
- 1-2 teaspoons dried Italian seasoning
- 2 cloves garlic, minced
- 2 tablespoons grated Parmesan cheese
- 1 beaten egg
- 6 small hoagie rolls
- 1 tablespoon olive oil
- 1/2 teaspoon garlic powder
- Salt to taste
- 1 (14 ounce) jar tomato and garlic pasta sauce
- 6 slices provolone cheese
When shopping for these ingredients, quality matters but doesn’t have to break the bank. For the ground beef, extra lean works best to avoid excessive grease, but you could substitute ground turkey if you prefer. The hoagie rolls should be fresh and sturdy enough to hold up to the sauce without getting soggy. And while jarred pasta sauce works perfectly, feel free to use homemade if you have some on hand. The beauty of this recipe is its adaptability—swap provolone for mozzarella, add red pepper flakes for heat, or toss in some fresh basil before serving for an elevated touch.
How to Make this Homemade Italian Meatball Sub

Making these Italian meatball subs is surprisingly straightforward, starting with perfectly seasoned, oven-baked meatballs.
Begin by preheating your oven to 350 degrees, then in a medium bowl, gently combine 1 pound of extra lean ground beef with 3/4 cup Italian seasoned breadcrumbs, 1-2 teaspoons of dried Italian seasoning, 2 minced garlic cloves, 2 tablespoons of grated Parmesan cheese, and 1 beaten egg. The key here is to mix everything just until combined—overworking the meat mixture will result in tough, dense meatballs that nobody wants.
Shape the mixture into 12 evenly-sized meatballs (about golf ball size works well), and place them in a lightly greased baking dish. Pop them in the oven for 25-30 minutes until they’re cooked through and slightly browned.
While those meatballs are working their magic in the oven, it’s time to prepare your bread and sauce. Take your 6 small hoagie rolls, split them down the middle, and brush the insides with 1 tablespoon of olive oil. Sprinkle with 1/2 teaspoon of garlic powder and a pinch of salt to taste. These simple additions transform ordinary bread into something that whispers sweet Italian nothings to your taste buds.
During the last 5 minutes of the meatballs’ cooking time, place your prepared hoagie rolls on a cookie sheet, cover with foil, and warm them in the oven alongside the meatballs. Meanwhile, pour a 14-ounce jar of tomato and garlic pasta sauce into a saucepan and warm it over medium heat until it’s gently bubbling.
Once the meatballs are done, transfer them directly into the warmed pasta sauce, gently coating each one. The marriage of flavors here is what makes this sub truly special—the savory meatballs soaking up that rich tomato sauce creates something greater than the sum of its parts.
For an extra-smooth sauce consistency, consider using a professional Vitamix blender to puree your favorite tomato sauce ingredients before warming.
Spoon 2 sauce-covered meatballs into each warmed hoagie roll, and top with a slice of provolone cheese. Return the assembled subs to the oven, covered with foil, for just 2-3 minutes until the cheese melts into a blanket of gooey perfection.
Allow them to cool slightly before serving—though I understand completely if you can’t wait that long. The first bite, with the crisp bread giving way to tender meatballs and stretchy cheese, might just make you wonder why you ever ordered takeout.
Homemade Italian Meatball Sub Substitutions and Variations
The beauty of this Italian meatball sub recipe lies in its flexibility—you can adapt it to your pantry contents or dietary preferences without sacrificing that classic comfort-food experience.
Need to go leaner? Try ground turkey or chicken instead of beef.
No Italian breadcrumbs? Regular breadcrumbs with extra Italian seasoning work perfectly.
Dairy-free? Skip the provolone and try a dairy-free cheese alternative or simply omit it.
You can also spice things up with red pepper flakes, swap in homemade marinara, or even use different rolls like ciabatta or French bread.
Who says comfort food can’t be customized?
What to Serve with Homemade Italian Meatball Sub
When you’ve got these saucy, cheesy meatball subs ready to devour, what else should grace your plate? I’m all about complementary sides that balance the rich, hearty nature of a good sub.
A crisp, vinegary coleslaw offers that perfect acidic contrast to cut through the fattiness.
Think about a simple arugula salad with lemon vinaigrette, too—those peppery greens just make sense.
Garlic-parmesan fries? Yes, please. They’re practically mandatory.
For something lighter, roasted veggies like bell peppers and zucchini echo those Italian flavors without weighing you down.
Final Thoughts
After enjoying these homemade meatball subs countless times, I’ve learned they’re more than just a sandwich—they’re a comfort food experience that brings people together.
There’s something magical about that first bite, when the cheese stretches between your mouth and the sandwich, the sauce drips down your fingers, and the meatballs deliver that perfect savory punch.
Whether you’re feeding a hungry family or hosting game day, these subs never disappoint.
The beauty lies in their simplicity. Good ingredients, a bit of patience, and voilà—a meal that feels like a warm hug on a plate.